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Article

Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19

16 Jun 2021

Abstract excerpt

Innate immunity triggers responsible for viral control or hyperinflammation in COVID-19 are largely unknown. Here we show that the SARS-CoV-2 spike protein (S-protein) primes inflammasome formation and release of mature interleukin-1β (IL-1β) in macrophages derived from COVID-19 patients but not in macrophages from healthy SARS-CoV-2 naïve individuals. Furthermore, longitudinal analyses reveal robust...

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PMID: 34133077
DOI: 10.15252/emmm.202114150

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