Article
SARS-CoV-2 ORF8 modulates lung inflammation and clinical disease progression.
PLoS pathogens - 1 May 2024
McGrath Marisa E, Xue Yong, Taylor Louis, Dillen Carly, Ardanuy Jeremy, Gonzalez-Juarbe Norberto, Baracco Lauren, Kim Raymond, Hart Rebecca, Assad-Garcia Nacyra, Vashee Sanjay, Frieman Matthew B
Abstract excerpt
The virus severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, is the causative agent of the current COVID-19 pandemic. It possesses a large 30 kilobase (kb) genome that encodes structural, non-structural, and accessory proteins. Although not necessary to cause disease, these accessory proteins are known to influence viral replication and pathogenesis. Through the synthesis of novel infectious clones of...
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