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Article

Astrocytic APOE4 genotype-mediated negative impacts on synaptic architecture in human pluripotent stem cell model.

Stem cell reports - 12 Sept 2023

Watanabe Hirotaka, Murakami Rei, Tsumagari Kazuya, Morimoto Satoru, Hashimoto Tadafumi, Imaizumi Kent, Sonn Iki, Yamada Kaoru, Saito Yuko, Murayama Shigeo, Iwatsubo Takeshi, Okano Hideyuki

Abstract excerpt

The APOE4 genotype is the strongest risk factor for the pathogenesis of sporadic Alzheimer's disease (AD), but the detailed molecular mechanism of APOE4-mediated synaptic impairment remains to be determined. In this study, we generated a human astrocyte model carrying the APOE3 or APOE4 genotype using human induced pluripotent stem cells (iPSCs) in which isogenic APOE4 iPSCs were genome edited from healthy...

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Identifiers

PMID: 37657448
DOI: 10.1016/j.stemcr.2023.08.002
PMCID: PMC10545487

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