Article

Modeling Cortical Versus Hippocampal Network Dysfunction in a Human Brain Assembloid Model of Epilepsy and Intellectual Disability

2024-09-08

Abstract excerpt

Neurodevelopmental disorders often impair multiple cognitive domains. For instance, a genetic epilepsy syndrome might cause seizures due to cortical hyperexcitability and present with memory impairments arising from hippocampal dysfunction. This study examines how a single disorder differentially affects distinct brain regions by using human patient iPSC-derived cortical- and hippocampal-ganglionic eminence assemb...

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Literature Corpus work: 6a1bfe0b-f974-5c52-ad6c-ba1d9e986350
DOI: 10.1101/2024.09.07.611739

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