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APOE4 impacts cortical neurodevelopment and alters network formation in human brain organoids

19 Jun 2025

Abstract excerpt

Apolipoprotein E4 (APOE4) is the leading genetic risk factor for Alzheimer's disease. While most studies examine the role of APOE4 in aging, APOE4 causes persistent changes in brain structure as early as infancy and is associated with altered functional connectivity that extends beyond adolescence. Here, we used human induced pluripotent stem cell-derived cortical and ganglionic eminence organoids (COs and GEOs)...

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PMID: 40541173
DOI: 10.1016/j.stemcr.2025.102537

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