Article

Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex

2022-09-14

Abstract excerpt

The slow delayed rectifier potassium current, I Ks , conducted through pore-forming Q1 and auxiliary E1 ion channel complexes is important for human cardiac action potential repolarization. During exercise or fright, I Ks is up-regulated by protein kinase A (PKA)-mediated Q1 phosphorylation to maintain heart rhythm and optimum cardiac performance. Sympathetic upregulation of I Ks requires recruitment of PKA hol...

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Literature Corpus work: ec1444ee-fa08-52ef-875e-72706dd9a1ea
DOI: 10.1101/2022.09.12.507626

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