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Article

Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel.

Science (New York, N.Y.) - 18 Jan 2002

Marx Steven O, Kurokawa Junko, Reiken Steven, Motoike Howard, D'Armiento Jeanine, Marks Andrew R, Kass Robert S

Abstract excerpt

Sympathetic nervous system (SNS) regulation of cardiac action potential duration (APD) is mediated by beta adrenergic receptor (betaAR) activation, which increases the slow outward potassium ion current (IKS). Mutations in two human I(KS) channel subunits, hKCNQ1 and hKCNE1, prolong APD and cause inherited cardiac arrhythmias known as LQTS (long QT syndrome). We show that betaAR modulation of I(KS) requires...

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Share to 8-Bromo Cyclic Adenosine Monophosphate
Share to A Kinase Anchor Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to KCNQ Potassium Channels

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Share to Potassium Channels, Voltage-Gated

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Share to Receptors, Adrenergic, beta

Source

Identifiers

PMID: 11799244
DOI: 10.1126/science.1066843

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel.PMID 11799244Read ↗

Mutation of an A-kinase-anchoring protein causes long-QT syndrome.Semantic proximity Read ↗

Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complexSemantic proximity Read ↗

The A-kinase anchoring protein Yotiao facilitates complex formation between adenylyl cyclase type 9 and the IKs potassium channel in heart.Semantic proximity Read ↗

Insights into Cardiac IKs (KCNQ1/KCNE1) Channels RegulationSemantic proximity Read ↗

Dominant-negative control of cAMP-dependent IKs upregulation in human long-QT syndrome type 1.Semantic proximity Read ↗

Proarrhythmic Consequences of a KCNQ1 AKAP-Binding Domain MutationSemantic proximity Read ↗

Gating and Regulation of KCNQ1 and KCNQ1 + KCNE1 Channel ComplexesSemantic proximity Read ↗

KV Channel-Interacting Proteins in Neurological and Cardiovascular System: An Updated ReviewSemantic proximity Read ↗

The fully activated open state of KCNQ1 controls the cardiac “fight-or-flight” responseSemantic proximity Read ↗

Secondary structure transitions and dual PIP2 binding define cardiac KCNQ1-KCNE1 channel gatingSemantic proximity Read ↗

A590T mutation in KCNQ1 C-terminal helix D decreases IKs channel trafficking and function but not Yotiao interaction.Semantic proximity Read ↗

Targeting the IKs Channel PKA Phosphorylation Axis to Restore Its Function in High-Risk LQT1 Variants.Semantic proximity Read ↗

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