Article

Secondary structure transitions and dual PIP2 binding define cardiac KCNQ1-KCNE1 channel gating

2025-06-10

Abstract excerpt

The KCNQ1+KCNE1 potassium channel complex forms the slow delayed rectifier current (I Ks ) critical for cardiac repolarization. Loss-of-function variants in KCNQ1 and KCNE1 cause long QT syndrome types 1 and 5 (LQT1/LQT5), accounting for over one-third of clinical LQTS cases. Despite prior structural work on KCNQ1 and KCNQ1+KCNE3, the structural basis of KCNQ1+KCNE1 remains unresolved. Using cryo-EM and electro...

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Literature Corpus work: 958a53f6-e5d7-53b9-b1f9-c95940744dbe
DOI: 10.1101/2025.06.10.657059

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