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A generic binding pocket for small molecule <i> I <sub>Ks</sub> </i> activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexes

2023-02-27

Abstract excerpt

The cardiac I Ks ion channel comprises KCNQ1, calmodulin, and KCNE1 in a dodecameric complex which provides a repolarizing current reserve at higher heart rates and protects from arrhythmia syndromes that cause fainting and sudden death. Pharmacological activators of I Ks are therefore of interest both scientifically and therapeutically for treatment of I Ks loss-of-function disorders. One group of chemical...

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Literature Corpus work
665b0a69-92f7-59f5-b5cd-a54cf41e3314
DOI
10.1101/2023.02.27.530167
Open publication

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A generic binding pocket for small molecule <i> I <sub>Ks</sub> </i> activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexesDOI 10.1101/2023.02.27.530167
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