Article

Precision Targeting of Troponin I Phosphorylation Prevents Diastolic Dysfunction while Preserving Systolic Performance

2025-11-18

Abstract excerpt

<h4>Background</h4> Defective cardiac relaxation (diastolic dysfunction) is prevalent in heart failure, particularly in the context of diabetes, obesity, hypertension, and ageing, and is associated with increased mortality. Yet there is no available treatment that directly targets this abnormal relaxation. Phosphorylation of troponin I by cAMP-dependent protein kinase A (PKA) promotes relaxation, but global PKA a...

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Literature Corpus work: 38f2b116-c55c-5ea3-8642-546bf763acaa
DOI: 10.1101/2025.11.18.689162

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