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Article

Long QT syndrome-associated mutations in KCNQ1 and KCNE1 subunits disrupt normal endosomal recycling of IKs channels.

Circulation research - 5 Dec 2008

Seebohm Guiscard, Strutz-Seebohm Nathalie, Ureche Oana N, Henrion Ulrike, Baltaev Ravshan, Mack Andreas F, Korniychuk Ganna, Steinke Katja, Tapken Daniel, Pfeufer Arne, Kääb Stefan, Bucci Cecilia, Attali Bernard, Merot Jean, Tavare Jeremy M, Hoppe Uta C, Sanguinetti Michael C, Lang Florian

Abstract excerpt

Physical and emotional stress is accompanied by release of stress hormones such as the glucocorticoid cortisol. This hormone upregulates the serum- and glucocorticoid-inducible kinase (SGK)1, which in turn stimulates I(Ks), a slow delayed rectifier potassium current that mediates cardiac action potential repolarization. Mutations in I(Ks) channel alpha (KCNQ1, KvLQT1, Kv7.1) or beta (KCNE1, IsK, minK) subunits...

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Source

Identifiers

PMID: 19008479
DOI: 10.1161/CIRCRESAHA.108.177360

Genes

KCNQ1
SGK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Long QT syndrome-associated mutations in KCNQ1 and KCNE1 subunits disrupt normal endosomal recycling of IKs channels.PMID 19008479Read ↗

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