Article

The fully activated open state of KCNQ1 controls the cardiac “fight-or-flight” response

2024-07-03

Abstract excerpt

The cardiac KCNQ1+KCNE1 (I Ks ) channel regulates heart rhythm in both normal and stress conditions. Under stress, the β-adrenergic stimulation elevates the intracellular cAMP level, leading to KCNQ1 phosphorylation by protein kinase A and increased I Ks , which shortens action potentials to adapt to accelerated heart rate. An impaired response to the β-adrenergic stimulation due to KCNQ1 mutations is associated...

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Literature Corpus work: 293f642b-c4ae-5c8b-a342-85304a3a24b9
DOI: 10.1101/2024.07.02.601749

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