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Article

Targeting the IKs Channel PKA Phosphorylation Axis to Restore Its Function in High-Risk LQT1 Variants.

Circulation research - 13 Sept 2024

Zhong Ling, Yan Zhenzhen, Jiang Dexiang, Weng Kuo-Chan, Ouyang Yue, Zhang Hangyu, Lin Xiaoqing, Xiao Chenxin, Yang Huaiyu, Yao Jing, Kang Xinjiang, Wang Changhe, Huang Chen, Shen Bing, Chung Sookja Kim, Jiang Zhi-Hong, Zhu Wandi, Neher Erwin, Silva Jonathan R, Hou Panpan

Abstract excerpt

BACKGROUND: The KCNQ1+KCNE1 (IKs) potassium channel plays a crucial role in cardiac adaptation to stress, in which β-adrenergic stimulation phosphorylates the IKs channel through the cyclic adenosine monophosphate (cAMP)/PKA (protein kinase A) pathway. Phosphorylation increases the channel current and accelerates repolarization to adapt to an increased heart rate. Variants in KCNQ1 can cause long-QT syndrome type...

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Source

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Identifiers

PMID: 39166328
DOI: 10.1161/CIRCRESAHA.124.325009
PMCID: PMC11392204

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Targeting the IKs Channel PKA Phosphorylation Axis to Restore Its Function in High-Risk LQT1 Variants.PMID 39166328Read ↗

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