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Article

C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon.

Human molecular genetics - 1 Oct 2006

Choe Chi-un, Schulze-Bahr Eric, Neu Axel, Xu Jun, Zhu Zheng I, Sauter Kathrin, Bähring Robert, Priori Silvia, Guicheney Pascale, Mönnig Gerold, Neapolitano Carlo, Heidemann Jan, Clancy Colleen E, Pongs Olaf, Isbrandt Dirk

Abstract excerpt

Beta-adrenergic receptor-mediated cAMP or protein kinase A (PKA)-dependent modulation of cardiac potassium currents controls ventricular action potential duration (APD) at faster heart rates. HERG (KCNH2) gene mutations are associated with congenital long-QT syndrome (LQT2) and affect IKr activity, a key determinant in ventricular repolarization. Physical activity or emotional stress often triggers lethal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16923798
DOI: 10.1093/hmg/ddl230

Genes

KCNH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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