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Article

Gating and Regulation of KCNQ1 and KCNQ1 + KCNE1 Channel Complexes

4 Jun 2020

Abstract excerpt

The IKs channel complex is formed by the co-assembly of Kv7.1 (KCNQ1), a voltage-gated potassium channel, with its β-subunit, KCNE1 and the association of numerous accessory regulatory molecules such as PIP2, calmodulin, and yotiao. As a result, the IKs potassium current shows kinetic and regulatory flexibility, which not only allows IKs to fulfill physiological roles as disparate as cardiac repolarization and...

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Identifiers

PMID: 32581825
DOI: 10.3389/fphys.2020.00504

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