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Article

A dual mechanism for I(Ks) current reduction by the pathogenic mutation KCNQ1-S277L.

Pacing and clinical electrophysiology : PACE - 1 Dec 2011

Chen Jerri, Weber Michael, Um Sung Yon, Walsh Christine A, Tang Yingying, McDonald Thomas V

Abstract excerpt

BACKGROUND: The hereditary long QT syndrome is characterized by prolonged ventricular repolarization that can be caused by mutations to the KCNQ1 gene, which encodes the α subunits of the cardiac potassium channel complex that carries the I(Ks) current (the β subunits are encoded by KCNE1). In th...

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Identifiers

PMID: 21895724
DOI: 10.1111/j.1540-8159.2011.03190.x
PMCID: PMC3237915

Genes

KCNQ1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21895724-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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A dual mechanism for I(Ks) current reduction by the pathogenic mutation KCNQ1-S277L.PMID 21895724Read ↗

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Biophysical properties of mutant KCNQ1 S277L channels linked to hereditary long QT syndrome with phenotypic variability.Semantic proximity Read ↗

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