Article

Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm

2024-05-30

Abstract excerpt

The molecular mechanisms that drive essential developmental patterning events in the mammalian embryo remain poorly understood. To generate a conceptual framework for gene regulatory processes during germ layer specification, we analyzed transcription factor (TF) expression kinetics around gastrulation and during in vitro differentiation. This approach identified Otx2 as a candidate regulator of definitive endoder...

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Literature Corpus work: 2672a9aa-de95-555f-a938-b14a21b7c3c2
DOI: 10.1101/2024.05.30.596630

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