Article

Hic2 fast-tracks iPS cell generation by suppressing KLF4-dependent epidermal detour

2025-09-11

Abstract excerpt

<h4>Summary</h4> Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) is the most established cellular conversion by exogenous master transcription factors (TFs). A deeper understanding of this yet inefficient process is critical to extending our capability to control cellular identity for medical applications. Here we report 14 genes essential for efficient iPSC generation, but dispensable for s...

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Literature Corpus work: ec106238-6dd4-5444-b65a-fd9d3d0fae8c
DOI: 10.1101/2025.09.11.675597

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