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Article

Tfcp2l1 safeguards the maintenance of human embryonic stem cell self-renewal.

Journal of cellular physiology - 1 Sept 2018

Sun Hongwei, You Yu, Guo Mengmeng, Wang Xiaohu, Zhang Yan, Ye Shoudong

Abstract excerpt

Tfcp2l1 is a transcription factor critical for mouse embryonic stem cell (mESC) maintenance. However, its role in human ESCs (hESCs) remains unclear. Here, we investigated the role of Tfcp2l1 in controlling hESC activity and showed that Tfcp2l1 is functionally important in the maintenance of hESC identity. Tfcp2l1 expression is highly enriched in hESCs and dramatically decreases upon differentiation. Forced...

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Body Patterning
Cell Self Renewal
Endoderm
Human Embryonic Stem Cells
Mesoderm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Domains

Structure-Activity Relationship

Wnt Signaling Pathway

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Identifiers

PMID: 29323720
DOI: 10.1002/jcp.26483
PMCID: PMC13482437

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