Article
Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation.
Nature communications - 22 Feb 2021
Jones Nicholas, Blagih Julianna, Zani Fabio, Rees April, Hill David G, Jenkins Benjamin J, Bull Caroline J, Moreira Diana, Bantan Azari I M, Cronin James G, Avancini Daniele, Jones Gareth W, Finlay David K, Vousden Karen H, Vincent Emma E, Thornton Catherine A
Abstract excerpt
Fructose intake has increased substantially throughout the developed world and is associated with obesity, type 2 diabetes and non-alcoholic fatty liver disease. Currently, our understanding of the metabolic and mechanistic implications for immune cells, such as monocytes and macrophages, exposed to elevated levels of dietary fructose is limited. Here, we show that fructose reprograms cellular metabolic pathways...
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