Article

Glucose Metabolism Mediates Feedback Control of Innate Immune Signaling in Human Macrophages

2026-08-17

Abstract excerpt

<h4>ABSTRACT</h4> Glucose metabolism is pivotal in regulating innate immune responses in primary human monocyte-derived macrophages (MDMs). Lipopolysaccharide (LPS) stimulation induces both inflammatory and antiviral programs; however, despite the established importance of glucose metabolism in these responses, its precise role in coordinating them remains poorly defined. Here, we identify the STAT1/NF-κB/IRF5 si...

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Literature Corpus work: a3c18e79-8ae4-5f7d-a073-f8101a40f7a9
DOI: 10.64898/2026.08.12.744460

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