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Article

Production of IL-6 and Phagocytosis Are the Most Resilient Immune Functions in Metabolically Compromised Human Monocytes.

Frontiers in immunology - 1 Jan 2021

Krauss Pierre-Louis, Pfeiffenberger Moritz, Damerau Alexandra, Buttgereit Thomas, Chen Yuling, Gaber Timo, Buttgereit Frank

Abstract excerpt

At sites of inflammation, monocytes carry out specific immune functions while facing challenging metabolic restrictions. Here, we investigated the potential of human monocytes to adapt to conditions of gradually inhibited oxidative phosphorylation (OXPHOS) under glucose free conditions. We used myxothiazol, an inhibitor of mitochondrial respiration, to adjust two different levels of decreased mitochondrial ATP...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34737742
DOI: 10.3389/fimmu.2021.730672
PMCID: PMC8562108

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