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Metabolic Stress Drives Keratinocyte Defenses against Staphylococcus aureus Infection

1 Mar 2017

Abstract excerpt

Human skin is commonly colonized and infected by Staphylococcus aureus. Exactly how these organisms are sensed by keratinocytes has not been clearly delineated. Using a combination of metabolic and transcriptomic methodologies, we found that S. aureus infection is sensed as a metabolic stress by the hypoxic keratinocytes. This induces HIF1α signaling, which promotes IL-1β production and stimulates aerobic...

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PMID: 28297676
DOI: 10.1016/j.celrep.2017.02.055

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