Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1.

doi:10.4049/jimmunol.1800002

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Article

Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2019

Freemerman Alex J, Zhao Liyang, Pingili Ajeeth K, Teng Bin, Cozzo Alyssa J, Fuller Ashley M, Johnson Amy R, Milner J Justin, Lim Maili F, Galanko Joseph A, Beck Melinda A, Bear James E, Rotty Jeremy D, Bezavada Lavanya, Smallwood Heather S, Puchowicz Michelle A, Liu Juan, Locasale Jason W, Lee Douglas P, Bennett Brian J, Abel E Dale, Rathmell Jeff C, Makowski Liza

Abstract excerpt

Macrophages (MΦs) are heterogeneous and metabolically flexible, with metabolism strongly affecting immune activation. A classic response to proinflammatory activation is increased flux through glycolysis with a downregulation of oxidative metabolism, whereas alternative activation is primarily oxidative, which begs the question of whether targeting glucose metabolism is a viable approach to control MΦ activation....

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PMID: 30659108
DOI: 10.4049/jimmunol.1800002
PMCID: PMC6360258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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