Article

Fatty acid metabolism in neutrophils promotes lung damage and bacterial replication during tuberculosis

2023-10-29

Abstract excerpt

<h4>ABSTRACT</h4> Mycobacterium tuberculosis (Mtb) infection triggers a significant influx of neutrophils to the lungs, which is linked to tuberculosis (TB) severity. The mechanism by which Mtb infection induces neutrophillic inflammation remains unclear. Using a clinically relevant and hypervirulent Mtb strain from the W-Beijing family, HN878, we found that genes related to both glycolysis and fatty acid metabol...

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Literature Corpus work: 5e448b81-f113-5893-ae3f-7bbcd86bc1b6
DOI: 10.1101/2023.10.25.563909

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