Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular mechanisms of neutrophil dysfunction in glycogen storage disease type Ib.

Blood - 1 May 2014

Jun Hyun Sik, Weinstein David A, Lee Young Mok, Mansfield Brian C, Chou Janice Y

Abstract excerpt

Glycogen storage disease type Ib (GSD-Ib) is an autosomal-recessive syndrome characterized by neutropenia and impaired glucose homeostasis resulting from a deficiency in the glucose-6-phosphate (G6P) transporter (G6PT). The underlying cause of GSD-Ib neutropenia is an enhanced neutrophil apoptosis, but patients also manifest neutrophil dysfunction of unknown etiology. Previously, we showed G6PT interacts with the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiporters
Share to Glucose-6-Phosphatase
Share to Glycogen Storage Disease Type I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Intracellular Space

Share to Lactic Acid

Share to Monosaccharide Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24565827
DOI: 10.1182/blood-2013-05-502435
PMCID: PMC4007611

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular mechanisms of neutrophil dysfunction in glycogen storage disease type Ib.PMID 24565827Read ↗

Glycogen storage disease type I and G6Pase-β deficiency: etiology and therapy.Semantic proximity Read ↗

Molecular mechanisms of aberrant neutrophil differentiation in glycogen storage disease type IbSemantic proximity Read ↗

Impaired glucose homeostasis, neutrophil trafficking and function in mice lacking the glucose-6-phosphate transporter.Semantic proximity Read ↗

Type I glycogen storage diseases: disorders of the glucose-6-phosphatase/glucose-6-phosphate transporter complexes.Semantic proximity Read ↗

Molecular mechanisms of aberrant neutrophil differentiation in glycogen storage disease type IbSemantic proximity Read ↗

Partial correction of neutrophil dysfunction by oral galactose therapy in glycogen storage disease type Ib.Semantic proximity Read ↗

Glucose-6-phosphate transporter mediates macrophage proliferation and functions by regulating glycolysis and mitochondrial respiration.Semantic proximity Read ↗

Type I glycogen storage diseases: disorders of the glucose-6-phosphatase complex.Semantic proximity Read ↗

Impaired neutrophil activity and increased susceptibility to bacterial infection in mice lacking glucose-6-phosphatase-beta.Semantic proximity Read ↗

G6PC3 mutations are associated with a major defect of glycosylation: a novel mechanism for neutrophil dysfunction.Semantic proximity Read ↗

The molecular basis of type 1 glycogen storage diseases.Semantic proximity Read ↗

Glucose-6-phosphatase mutation G188R confers an atypical glycogen storage disease type 1b phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.