Article

Pioneer transcription factors are associated with the modulation of DNA methylation patterns across cancers

2021-05-10

Abstract excerpt

Methylation of cytosines on DNA is a prominent modification associated with gene expression regulation. Aberrant DNA methylation patterns have recurrently been linked to dysregulation of the regulatory program in cancer cells. To shed light on the underlying molecular mechanism driving this process, we hypothesized that aberrant methylation patterns could be controlled by the binding of specific transcription fact...

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Literature Corpus work: ebd8b3ef-f0a3-5cd3-857a-dc1988cc916d
DOI: 10.1101/2021.05.10.443359

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