Article
Genome-wide quantification of the effects of DNA methylation on human gene regulation
2017-06-07
Abstract excerpt
Changes in DNA methylation are important in development and disease, but not all regulatory elements act in a methylation-dependent (MD) manner. Here, we developed mSTARR-seq, a high-throughput approach to quantify the effects of DNA methylation on regulatory element function. We assay MD activity in 14% of the euchromatic human genome, identify 2,143 MD regulatory elements, and predict MD activity using sequence...
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Identifiers and source
- Literature Corpus work
- 22afac90-c0b4-5a3e-84b7-d61977ef0dff
- DOI
- 10.1101/146829