Article

De-novo DNA Methylation of Bivalent Promoters Induces Gene Activation through PRC2 Displacement

2025-02-08

Abstract excerpt

Promoter DNA methylation is a key epigenetic mark, commonly associated with gene silencing. However, we noticed that a positive association between promoter DNA methylation and expression is surprisingly common in cancer. Here, we use hit-and-run CRISPR/dCas9 epigenome editing to evaluate how deposition of DNA methylation can regulate gene expression dependent on pre-existing chromatin environment. While the predo...

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Literature Corpus work: d738c036-603e-5845-9355-1cdc70c4de45
DOI: 10.1101/2025.02.07.636872

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