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Article

Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression.

Nature genetics - 1 Nov 2012

Cowper-Sal lari Richard, Zhang Xiaoyang, Wright Jason B, Bailey Swneke D, Cole Michael D, Eeckhoute Jerome, Moore Jason H, Lupien Mathieu

Abstract excerpt

Genome-wide association studies (GWAS) have identified thousands of SNPs that are associated with human traits and diseases. But, because the vast majority of these SNPs are located in non-coding regions of the genome, the mechanisms by which they promote disease risk have remained elusive. Employing a new methodology that combines cistromics, epigenomics and genotype imputation, we annotate the non-coding...

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Identifiers

PMID: 23001124
DOI: 10.1038/ng.2416
PMCID: PMC3483423

Genes

FOXA1
ESR1
TOX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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