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Article

Impact of mutations in DNA methylation modification genes on genome-wide methylation landscapes and downstream gene activations in pan-cancer.

BMC medical genomics - 24 Feb 2020

Lee Chai-Jin, Ahn Hongryul, Jeong Dabin, Pak Minwoo, Moon Ji Hwan, Kim Sun

Abstract excerpt

BACKGROUND: In cancer, mutations of DNA methylation modification genes have crucial roles for epigenetic modifications genome-wide, which lead to the activation or suppression of important genes including tumor suppressor genes. Mutations on the epigenetic modifiers could affect the enzyme activity, which would result in the difference in genome-wide methylation profiles and, activation of downstream genes....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32093698
DOI: 10.1186/s12920-020-0659-4
PMCID: PMC7038532

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