Article

Base-resolution DNA methylome of human MDS hematopoietic stem cell reveals TET2-GFI1 epigenetic axis repressing MDS

2026-02-11

Abstract excerpt

Dysfunctional hematopoietic stem cells (HSCs) drive the initiation of myelodysplastic syndromes (MDS), yet the genome-wide DNA methylation landscape in MDS primitive HSCs and its mechanistic contribution to disease pathogenesis remain poorly defined. Here, we establish single-base resolution DNA methylomes of bone marrow HSCs from MDS patients and healthy donors. We uncover widespread hypermethylation within CpG i...

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Literature Corpus work: a0b73d22-4090-5c32-ad69-6bdc9733cb99
DOI: 10.64898/2026.02.10.704995

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