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Article

Conserved methylation signatures associate with the tumor immune microenvironment and immunotherapy response

2 Apr 2024

Abstract excerpt

BACKGROUND: Aberrant DNA methylation is a major characteristic of cancer genomes. It remains unclear which biological processes determine epigenetic reprogramming and how these processes influence the variants in the cancer methylome, which can further impact cancer phenotypes. METHODS: We performed pairwise permutations of 381,900 loci in 569 paired DNA methylation profiles of cancer tissue and matched normal...

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PMID: 38566132
DOI: 10.1186/s13073-024-01318-3

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