Article

Comprehensive Analysis of Co-Mutations Identifies Cooperating Mechanisms of Tumorigenesis

2021-08-24

Abstract excerpt

Somatic mutations are one of the most important factors in tumorigenesis and are the focus of most cancer sequencing efforts. The co-occurrence of multiple mutations in one tumor has gained increasing attention as a means of identifying cooperating mutations or pathways that contribute to cancer.Using multi-omics, phenotypical, and clinical data from 29,559 cancer subjects and 1,747 cancer cell lines covering 78 d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eb910dcb-9922-55e5-a1b5-5fa0d432b842
DOI: 10.1101/2021.08.23.457315

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comprehensive Analysis of Co-Mutations Identifies Cooperating Mechanisms of TumorigenesisDOI 10.1101/2021.08.23.457315Read

A Pan-Cancer Assessment of RB1/TP53 Co-MutationsSemantic proximity Read

Evolving patterns of co-mutations from tumor initiation to metastatic progression.Semantic proximity Read

Unbiased co-occurring mutational landscapes in tumorigenesisSemantic proximity Read

Cancer-Type Specific Prognostic Impact of Concurrent TP53 and KRAS Alterations: A Multi-Cohort Genomic AnalysisSemantic proximity Read

CoMutDB: the landscape of somatic mutation co-occurrence in cancers.Semantic proximity Read

Co-occurring Mutations in Different Genes Can Fuel Oncogenic Signaling and Serve as Metastatic Tumor MarkersSemantic proximity Read

A network of cancer genes with co-occurring and anti-co-occurring mutations.Semantic proximity Read

Methods for detecting co-mutated pathways in cancer samples to inform treatment selectionSemantic proximity Read

Oncogenic composite mutations can be predicted by co-mutations and their chromosomal location.Semantic proximity Read

Co-mutation and exclusion analysis in human tumors, a means for cancer biology studies and treatment designSemantic proximity Read

Co-occurring mutations identify prognostic subgroups of microsatellite stable colorectal cancer.Semantic proximity Read

Co-occurrence and mutual exclusivity: what cross-cancer mutation patterns can tell us.Semantic proximity Read