Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Co-occurring mutations identify prognostic subgroups of microsatellite stable colorectal cancer.

Molecular cancer - 25 Nov 2024

Nunes Luís, Stenersen Jakob Mørkved, Kryeziu Kushtrim, Sjöblom Tobias, Glimelius Bengt, Lothe Ragnhild A, Sveen Anita

Abstract excerpt

BACKGROUND: Co-occurring mutations in pairs of genes can pinpoint clinically relevant subgroups of cancer. Most colorectal cancers (CRCs) are microsatellite stable (MSS) and have few frequent mutations. Large patient cohorts and broad genomic coverage are needed for comprehensive co-mutation profiling. METHODS: Co-mutations were identified in a population-based Swedish cohort analyzed by whole-genome sequencing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microsatellite Instability

Share to Microsatellite Repeats

Share to Neoplasm Staging

Share to Prognosis

Share to Sweden

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 39587554
DOI: 10.1186/s12943-024-02173-x
PMCID: PMC11587607

Genes

APC
TCF7L2
BRAF
IMPACT
KRAS
PIK3CA
RNF43
SOX9
TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Co-occurring mutations identify prognostic subgroups of microsatellite stable colorectal cancer.PMID 39587554Read ↗

Comprehensive Analysis of Co-Mutations Identifies Cooperating Mechanisms of TumorigenesisSemantic proximity Read ↗

Oncologic relevance of genetic alterations in sporadic synchronous and solitary colorectal cancer: a retrospective multicenter study.Semantic proximity Read ↗

Oncologic relevance of genetic alterations in sporadic synchronous and solitary colorectal cancer: a retrospective multicenter studySemantic proximity Read ↗

Evolving patterns of co-mutations from tumor initiation to metastatic progression.Semantic proximity Read ↗

APC and PIK3CA Mutational Cooperativity Predicts Pathologic Response and Survival in Patients Undergoing Resection for Colorectal Liver Metastases.Semantic proximity Read ↗

Same-Cell Co-Occurrence of RAS Hotspot and BRAF V600E Mutations in Treatment-Naive Colorectal Cancer.Semantic proximity Read ↗

Genetic heterogeneity in synchronous colorectal cancers impacts genotyping approaches and therapeutic strategies.Semantic proximity Read ↗

The molecular landscape of synchronous colorectal cancer reveals genetic heterogeneity.Semantic proximity Read ↗

CMS-dependent prognostic impact of KRAS and BRAFV600E mutations in primary colorectal cancer.Semantic proximity Read ↗

A Pan-Cancer Assessment of RB1/TP53 Co-MutationsSemantic proximity Read ↗

Unbiased co-occurring mutational landscapes in tumorigenesisSemantic proximity Read ↗

Co-occurring Mutations in Different Genes Can Fuel Oncogenic Signaling and Serve as Metastatic Tumor MarkersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.