Article

Unbiased co-occurring mutational landscapes in tumorigenesis

2025-01-22

Abstract excerpt

<h4>Summary</h4> Mutations with a synergistic effect on tumorigenesis were positively selected during tumor evolution, showing a tendency to co-occur in cancer genomes. To systematically gain insight of tumorigenic crosstalk at the mutation level, we utilized the FP-Growth algorithm in frequent pattern mining to create an unbiased map of co-occurring mutations from clinical genome sequencing data. We identified 1...

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Literature Corpus work: df46996d-2dac-5021-8d66-c510223d1b82
DOI: 10.1101/2025.01.19.633809

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