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A Pan-Cancer Assessment of RB1/TP53 Co-Mutations

30 Aug 2022

Abstract excerpt

Nearly all tumors have multiple mutations in cancer-causing genes. Which of these mutations act in tandem with other mutations to drive malignancy and also provide therapeutic vulnerability? To address this fundamental question, we conducted a pan-cancer screen of co-mutation enrichment (looking for two genes mutated together in the same tumor at a statistically significant rate) using the AACR-GENIE 11.0 data...

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PMID: 36077736
DOI: 10.3390/cancers14174199

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