Article
Oncogenic composite mutations can be predicted by co-mutations and their chromosomal location.
Molecular oncology - 1 Oct 2024
Küçükosmanoglu Asli, van der Borden Carolien L, de Boer Lisanne E A, Verhaak Roel, Noske David, Wurdinger Tom, Radonic Teodora, Westerman Bart A
Abstract excerpt
Genetic heterogeneity in tumors can show a remarkable selectivity when two or more independent genetic events occur in the same gene. This phenomenon, called composite mutation, points toward a selective pressure, which frequently causes therapy resistance to mutation-specific drugs. Since composite mutations have been described to occur in sub-clonal populations, they are not always captured through biopsy...
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