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Article

Evolving patterns of co-mutations from tumor initiation to metastatic progression.

Nature genetics - 1 Aug 2026

Iyer Arvind, Petrovic Miljan, Sesia Debora, Nanni Luca, Mina Marco, Ciriello Giovanni

Abstract excerpt

Phenotypically healthy cells frequently harbor somatic variants at cancer-associated genes, indicating that malignant transformation requires the selection of several alterations. Predicting which combinations of mutations, or co-mutations, exhibit oncogenic capacity requires identifying co-mutations that occur more or less frequently than expected. However, statistical frameworks to solve this problem are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42432246
DOI: 10.1038/s41588-026-02661-4
PMCID: PMC13447111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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