Article

Co-occurring Mutations in Different Genes Can Fuel Oncogenic Signaling and Serve as Metastatic Tumor Markers

2024-05-03

Abstract excerpt

Interrogation of big genomic data and integration with large-scale protein-protein interaction networks and pathways, can provide deep patterns that are rare– yet can prompt dramatic phenotypic alterations and serve as clinical signatures. Mapping cancer-specific co-occurring mutation-pair signatures, in primary and metastatic tumors, is indispensable in precision oncology. The additivity of co-occurring driver mu...

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Literature Corpus work: bba6bfd9-3289-5fde-b5a1-3eb77635899d
DOI: 10.1101/2024.05.01.592039

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