Article

Polymorphisms of the Glucocorticoid Receptor Gene and Adrenal Suppression in Patients with Chronic Obstructive Pulmonary Disease Treated with Glucocorticoids for Acute Exacerbations

2020-12-16

Abstract excerpt

<h4>Background: </h4> Single-nucleotide polymorphisms (SNPs) of the glucocorticoid receptor (GR) gene NR3C1 have been associated with an altered sensitivity to glucocorticoids (GC), and thus may affect the therapeutic effects of GCs. We investigated the prevalence of adrenal suppression after treatment with GCs and evaluated whether GR SNPs were associated with the risk of adrenal suppression and metabolic disorde...

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Literature Corpus work: eb786b5c-fd5d-574a-80c5-9b7d90a6399b
DOI: 10.21203/rs.3.rs-126008/v1

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