HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma.

doi:10.1073/pnas.1918819117

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Article

HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma.

Proceedings of the National Academy of Sciences of the United States of America - 28 Jan 2020

Zein Joe, Gaston Benjamin, Bazeley Peter, DeBoer Mark D, Igo Robert P, Bleecker Eugene R, Meyers Deborah, Comhair Suzy, Marozkina Nadzeya V, Cotton Calvin, Patel Mona, Alyamani Mohammad, Xu Weiling, Busse William W, Calhoun William J, Ortega Victor, Hawkins Gregory A, Castro Mario, Chung Kian Fan, Fahy John V, Fitzpatrick Anne M, Israel Elliot, Jarjour Nizar N, Levy Bruce, Mauger David T, Moore Wendy C, Noel Patricia, Peters Stephen P, Teague W Gerald, Wenzel Sally E, Erzurum Serpil C, Sharifi Nima

Abstract excerpt

Asthma resistance to glucocorticoid treatment is a major health problem with unclear etiology. Glucocorticoids inhibit adrenal androgen production. However, androgens have potential benefits in asthma. HSD3B1 encodes for 3β-hydroxysteroid dehydrogenase-1 (3β-HSD1), which catalyzes peripheral conversion from adrenal dehydroepiandrosterone (DHEA) to potent androgens and has a germline missense-encoding...

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PMID: 31932420
DOI: 10.1073/pnas.1918819117
PMCID: PMC6995013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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