Article
Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study.
The Lancet. Respiratory medicine - 1 Jun 2018
Hawcutt Daniel B, Francis Ben, Carr Daniel F, Jorgensen Andrea L, Yin Peng, Wallin Naomi, O'Hara Natalie, Zhang Eunice J, Bloch Katarzyna M, Ganguli Amitava, Thompson Ben, McEvoy Laurence, Peak Matthew, Crawford Andrew A, Walker Brian R, Blair Joanne C, Couriel Jonathan, Smyth Rosalind L, Pirmohamed Munir
Abstract excerpt
BACKGROUND: A serious adverse effect of corticosteroid therapy is adrenal suppression. Our aim was to identify genetic variants affecting susceptibility to corticosteroid-induced adrenal suppression. METHODS: We enrolled children with asthma who used inhaled corticosteroids as part of their treatment from 25 sites across the UK (discovery cohort), as part of the Pharmacogenetics of Adrenal Suppression with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.