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Article

Variants in the Glucocorticoid Receptor gene (NR3C1), asthma control and serum cytokine levels.

Respiratory medicine - 1 Jan 2026

de Santana Maria Borges Rabêlo, Cruz Álvaro A, de Araújo João Locke Ferreira, Tugores Rafaela Machado, Teixeira Helena Mariana Pitangueira, de Jesus Talita Santos, Pimentel Gabriela, Santana Cinthia Vila Nova, Kermani Nazanin Zounemat, Chung Kian Fan, Adcock Ian M, Souza-Machado Adelmir, Figueiredo Camila Alexandrina, Dos Santos Costa Ryan

Abstract excerpt

INTRODUCTION: Asthma is a heterogeneous disease usually treated with inhaled corticosteroids (ICS) and long-acting beta2 agonists. However, not all individuals achieve adequate control with ICS. AIM: To identify genetic variants in the glucocorticoid receptor gene (NR3C1) associated with asthma endophenotypes, bronchodilator reversibility, and asthma control under medium-to-high ICS doses. METHODS: Association...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41352569
DOI: 10.1016/j.rmed.2025.108553

Genes

NR3C1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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