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Article

The N363S and I559N single nucleotide polymorphisms of the h-GR/NR3C1 gene in patients with bronchial asthma.

International journal of molecular medicine - 1 Jul 2012

Panek Michał, Pietras Tadeusz, Antczak Adam, Fabijan Artur, Przemęcka Marcelina, Górski Paweł, Kuna Piotr, Szemraj Janusz

Abstract excerpt

Bronchial asthma is a disease of multifactorial etiology. The natural variability of the DNA sequence within the h-GR/NR3C1 gene affects both the conformation and the activity of glucocorticoid receptors. There are 2 major types of resistance to glucocorticoids (GCS)-resistant asthma failing to respond to treatment with high doses of inhaled and oral glucocorticoids. Type I GCS-resistant asthma is...

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Identifiers

PMID: 22469783
DOI: 10.3892/ijmm.2012.956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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