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Article

Effect of glucocorticoid receptor gene polymorphisms on asthma phenotypes

13 Nov 2012

Abstract excerpt

The clinical presentation of asthma results from complex gene-gene and gene-environment interactions. The natural variability of the DNA sequence within the NR3C1 gene affects the activity of glucocorticoid receptors (GCRs). The NR3C1 gene is localized on chromosome 5q31-q32. The gene coding for the GCR comprises nine exons. The structural domains of the GCR determine the biological functions of the functional...

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PMID: 23407653
DOI: 10.3892/etm.2012.809

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