Article
Adrenal suppression in patients with chronic obstructive pulmonary disease treated with glucocorticoids: Role of specific glucocorticoid receptor polymorphisms.
PloS one - 1 Jan 2022
Sivapalan Pradeesh, Borresen Stina Willemoes, Eklöf Josefin, Klose Marianne, Holm Freja S, Feldt-Rasmussen Ulla, Rossing Maria, Jørgensen Niklas R, Marvig Rasmus L, Saeed Mohamad Isam, Wilcke Torgny, Seersholm Niels, Mathioudakis Alexander G, Vestbo Jørgen, Jensen Jens-Ulrik Stæhr
Abstract excerpt
BACKGROUND: Single-nucleotide polymorphisms (SNPs) of the glucocorticoid receptor (GR) gene NR3C1 have been associated with an altered sensitivity to glucocorticoids, and thus may alter the therapeutic effects of glucocorticoids. We investigated the prevalence of adrenal suppression after treatment with glucocorticoids and evaluated whether GR SNPs were associated with altered risks of adrenal suppression and...
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