Molecular mechanisms of glucocorticoid resistance.

doi:10.1111/eci.13901

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Article

Molecular mechanisms of glucocorticoid resistance.

European journal of clinical investigation - 1 Feb 2023

Huang Huanming, Wang Wenqing

Abstract excerpt

BACKGROUND: As a powerful anti-inflammatory, immunosuppressive, and antiproliferative drug, glucocorticoid (GC) plays an important role in the treatment of various diseases. However, some patients may experience glucocorticoid resistance (GCR) in clinical, and its molecular mechanism have not been determined. METHODS: The authors performed a review of the literature on GCR focusing on mutations in the NR3C1 gene...

Topics

Signal Transduction
Receptors, Glucocorticoid
Glucocorticoids
Mutation
Humans
Drug Resistance
Metabolism, Inborn Errors

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Open in PubMed

Identifiers

PMID: 36346177
DOI: 10.1111/eci.13901

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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