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Article

Cytosolic sensing of aberrant DNA: arming STING on the endoplasmic reticulum

28 Jul 2015

Abstract excerpt

INTRODUCTION: Detection of pathogen-derived nucleic acids is a general and effective strategy used by the host to perceive the presence of invading microorganisms and initiate an innate immune response. However, inappropriate detection of aberrant self nucleic acids is implicated in the development of autoimmune diseases. Recently, ER-resident stimulator of interferon genes (STING) has been uncovered as a key...

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PMID: 26220155
DOI: 10.1517/14728222.2015.1067303

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