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Article

Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseases

1 Jun 2023

Abstract excerpt

Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is a DNA sensor that elicits a robust type I interferon response by recognizing ubiquitous danger-associated molecules. The cGAS/stimulator of interferon genes (cGAS/STING) is activated by endogenous DNA, including DNA released from mitochondria and extranuclear chromatin, as well as exogenous DNA derived from pathogenic...

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PMID: 37354378
DOI: 10.1007/s12272-023-01452-3

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